The COPD Foundation’s COPD360Net Initiative Approach to Patient-Centric Drug Development: A Case Study in Using Patient Surveys to Inform New Treatments for Viral Respiratory Infections

Tal-Singer, et al; “The COPD Foundation’s COPD360Net Initiative Approach to Patient-Centric Drug Development: A Case Study in Using Patient Surveys to Inform New Treatments for Viral Respiratory Infections“; Journal of Patient Experience, 2023 https://doi.org/10.1177/23743735231151554

Safety and Tolerability of the Toll-Like Receptor (TLR)2/6 Agonist INNA-051 in Healthy Adults

White et al; “Safety and Tolerability of the Toll-Like Receptor (TLR)2/6 Agonist INNA-051 in Healthy Adults“; ENA Respiratory, 2022 View poster

TLR-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs.

Deliyannis et al; “TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs“; JCI Insight, 2021 https://doi.org/10.1172/jci.insight.140267

TLR2-mediated innate immune priming boosts lung anti-viral immunity

Girkin et al; “TLR2-mediated innate immune priming boosts lung anti-viral immunity“; European Respiratory Journal, 2020 https://doi.org/10.1183/13993003.01584-2020

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

Proud et al; “Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model“; EBioMedicine, 2020 https://doi.org/10.1016/j.ebiom.2020.103153

Reducing the impact of influenza-associated secondary pneumococcal infections

Mifsud et al; “Reducing the impact of influenza-associated secondary pneumococcal infections“; Immunol. Cell Biol, 2015 https://doi.org/10.1038/icb.2015.71

Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam2Cys

Mifsud et al; “Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam2Cys“; Front Immunol, 2015 https://doi.org/10.3389/fimmu.2015.00290

Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice

Tan et al; “Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice“; Mol. Pharm, 2012 https://doi.org/10.1021/mp300257x